Ebrahim Shirzadeh; Hasan Abollahzadeh
Volume 18, Issue 4 , January and February 2012, , Pages 302-305
Abstract
A three-day-old Iranian female neonate being the product of an uncomplicated pregnancy was admitted to the ophthalmology office with severe abnormality of the left and right eyes. Family history، drug history and maternal diseases during pregnancy were negative and there was no history of consanguinity. ...
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A three-day-old Iranian female neonate being the product of an uncomplicated pregnancy was admitted to the ophthalmology office with severe abnormality of the left and right eyes. Family history، drug history and maternal diseases during pregnancy were negative and there was no history of consanguinity. Breastfeeding was normal and there was no problem of feeding and breathing. There were complete absence of both eyebrows and complete absence of lids in the left eye as well as an incomplete lid defect in the right eye. Slit lamp examination of the right eye showed remnants of incomplete upper lid margin with some eyelashes attached to the upper half of cornea. Part of anterior chamber and iris were visible from lower half of the right cornea. Pupil was not observable. Right lower lid had two layers with its inner layer attached to the lower part of cornea. Except for the pulling of the left nostril and nose toward the left cheek، other parts including the lips، mouth، tongue، palate and pharynx seemed normal. Also، she had partial syndactyly of the right hand and left foot. By parents’ statement، genitourinary tract and bowel tract had no abnormality. The diagnosis was cryptophthalmos-syndactyly syndrome. The purpose of this presentation is to report a new and severe case of bilateral cryptophthalmos-syndactyly.
Ebrahim Shirzadeh
Volume 17, Issue 4 , January and February 2011, , Pages 301-303
Abstract
A four-year-old girl referred to the ophthalmologist for evaluation of swelling and lesions on lids, nose and upper lip. In history by her mother’s statement, the patient developed lesions following a severe fever. The child did not indicate other problems. Clinical examination showed swelling, vesicle ...
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A four-year-old girl referred to the ophthalmologist for evaluation of swelling and lesions on lids, nose and upper lip. In history by her mother’s statement, the patient developed lesions following a severe fever. The child did not indicate other problems. Clinical examination showed swelling, vesicle lesions on lids (both eyes) and the upper lip and vesicle blister, crust and ulcerative lesions on dorsal and nasal bridge. Based on typical blister lesions of lids, nose and lip, the diagnosis was herpes simplex lesions. In a newborn, severely malnourished infants and immunocompromised persons, a serious infection may occur. The purpose of this clinical presentation is to report a severe and unusual clinical case of herpes simplex infection in an immunocompetent child.
Rahim Golmohammadi; Ebrahim Shirzadeh
Volume 15, Issue 4 , January and February 2009, , Pages 226-230
Abstract
Background and Purpose: Technology has caused great progress in the novel molecular diagnosis and research methods in medical laboratory. Novel methods have also led to the higher accuracy rates in laboratory procedures which are of considerable importance in clinical follow-up of genetic diseases. Therefore ...
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Background and Purpose: Technology has caused great progress in the novel molecular diagnosis and research methods in medical laboratory. Novel methods have also led to the higher accuracy rates in laboratory procedures which are of considerable importance in clinical follow-up of genetic diseases. Therefore this study is intended to investigate factors affecting gene amplification in polymerase chain reaction in order to enhance diagnostic accuracy. Materials and Methods: This deh1ive analytical research was conducted on 61 adenocarcinoma specimens in the cellular and molecular departments of Sabzevar and Isfahan Universities of Medical Sciences in Iran. DNA was extracted by the standard kit; then the segment AURKA gene and P53 Gene were amplified using two pairs of specific primers and different concentration Mgcl2 in a PCR assay. PCR product was electrophoresized in agarose gel. Results: Electrophoresis of PCR product with Mgcl2 concentrations of 3 and 5 mm was better than 1.5 mm. The primer with concentration of 1 mm was better than 5 and 10 mm. From the two pairs of primers used in amplifying AURKA gene axon 4 one pair of primers was better than the other pair. From the two pairs of primers used for amplifying the axon 5 of P53 gene in PCR assay one pair was better than the other. Conclusions: Primer type and concentration of Mgcl2 are important in amplifying genes in the polymerase chain reaction assay.
AA BOLOURIAN; E SHIRZADEH
Volume 14, Issue 3 , September and October 2007, , Pages 179-184
Abstract
Background and Purpose: Pinguecula causes cosmetic effects and induces pterygium in some cases. Burning, irritation, lacrimation and foreign body sensation, occasional significant astigmatism and decreased vision are among the major symptoms of pterygium. As most findings in this regard are hospital-based, ...
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Background and Purpose: Pinguecula causes cosmetic effects and induces pterygium in some cases. Burning, irritation, lacrimation and foreign body sensation, occasional significant astigmatism and decreased vision are among the major symptoms of pterygium. As most findings in this regard are hospital-based, the present population- based study was conducted to study the prevalence of pterygium and pinguecula and the effect of population variables in the rural population of sabzevar, Iran.
Methods and Materials: This descriptive epidemiologic study was conducted cross- sectionally and the population was rural residents in sabzevar, Iran. Cluster sampling was used for random sampling from 40 villages amounting to 2508 subjects.
The study was conducted in 2002-2004. The subjects were interviewed and fully examined. Diagnoses were made clinically.
The relationships between population variables and the two disorders were evaluated. The obtained data were analyzed using chi- square, t- test and logistic regression.
Results: Mean age of 1014 men (40.5%) and 1494 women (59.5%) participating in the study were 27.84± 22.07 and 26.90± 19.05 years respectively. Of 2508 subjects, 396 cases of pterygium and pinguecula were diagnosed with an overall prevalence of 15.8%; 187 men (18.44%) and 209 women (14%). Its prevalence was higher in men than in women. Its distribution as asymmetric, i.e. OD: OS ratio = 0.64. Also, its prevalence across different jobs rendered the following results for farmers, workers and housewives: 39.5; 33.3 and 23 respectively:
Conclusion: The overal prevalence of pterygium and pinguecula in rural population of Sabzevar is 15.7%, which may be attributed to population variables and risk factors, geographical location, climatic conditions, racial and familial factors.
E SHIRZADEH; AA BOLOURIAN
Volume 14, Issue 1 , March and April 2007, , Pages 38-43
Abstract
Background and purpose: Cataract is the lens opacity which brings about vision disorders and is generally divided into four types: congenital, traumatic, secondary and age-related. It is commonly a disease of middle-age and geriatric age and the main factor in low vision and blindness throughout the ...
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Background and purpose: Cataract is the lens opacity which brings about vision disorders and is generally divided into four types: congenital, traumatic, secondary and age-related. It is commonly a disease of middle-age and geriatric age and the main factor in low vision and blindness throughout the world. This study is intended to survey the prevalence of cataract in the rural population of Sabzevar in Iran.
Methods and Materials: This research is a cross-sectional epidemiological descriptive study. 40 villages were selected through cluster sampling and the statistical population included all rural residents in 2002-2004 (1381-1383). 2805 subjects (with the age range of 11 days to 92 years old) participated in the primary screening which consisted of tests of visual acuity, red reflex, retinoscopy and the examination of anterior segment via torch or ophthalmoscope. Subjects with visual disorders or defected red reflex were referred to ophthalmologist for complete examinations.
Results: Mean age for 1014 male (40.5%) and 1494 female (59.5%) were 27.84±22.07 and 27.90±19.05 years respectively.
The overall prevalence of cataract was 6% (confidence interval 95%). Its prevalence in men and women were 7.8% and 4.8% respectively.
Conclusion: Regarding the limited number of similar epidemiological studies in Iran, further studies can be helpful in estimating the magnitude of cataract and visual disorders due to cataract in the rural population since estimating the magnitude of this controllable disease can be of considerable personal, social and economical advantages.
R GOLMOHAMMADI; E SHIRZADEH; R KHASHEEI
Volume 12, Issue 2 , July and August 2005, , Pages 20-25
Abstract
Background and Purpose: Rubella is a member of togaviridate viruses, with minor morbidity in children. Rubella infection during pregnancy causes various malformations including congenital cataract. Immunity against it is, therefore, important in girls before marriage and it is recommended in girls without ...
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Background and Purpose: Rubella is a member of togaviridate viruses, with minor morbidity in children. Rubella infection during pregnancy causes various malformations including congenital cataract. Immunity against it is, therefore, important in girls before marriage and it is recommended in girls without antirubella antibody in some countries. This study is intended to determine the anti-rubella immunity in premarriage girls in Sabzevar, Iran.
Methods and Materials: This descriptive-analytical study was conducted on 186 pre-marriage girls in Sabzevar, Iran to determine serological anti-rubella (IgG and IgM)using ELlSA. NOVUM DIAGNOSTICA Kit was used for tests and SPSS for data analysis.
Results: 172 girls (92.5%) were positive and 14 girls (7.5%) negative, Le. high risk group.152 girls (81.7%) already infected with rubella were now positive and 11 girls (5.9%) negative.
Conclusion: Subjects' age and IgG antibody did not show any significant relationships while a significant relationship was found between exposure to rubella and IgG (p